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• One of the most significant challenges facing biotechnology companies is securing adequate funding to sustain research and development efforts.
• Calidi’s improved financial footing reassures investors and allows the company to focus on achieving key milestones in its research pipeline.
• The company has been selected to present new data on its RTNova systemic virotherapy platform at the prestigious AACR annual meeting in April 2025.

Calidi Biotherapeutics (NYSE American: CLDI), a clinical-stage biotechnology company, is making significant strides in the field of cancer immunotherapy. Known for its innovative approach to antitumor virotherapies, Calidi is focused on harnessing the power of its patented technology that protects and potentiates the virotherapy during administration (extracellular enveloped viruses in its systemic platform and stem cells in its intratumoral platforms) to target and destroy cancer cells while simultaneously stimulating the immune system. The company’s groundbreaking work has positioned it as a leader in the development of next-generation cancer treatments.

In recent news, Calidi has made two major announcements that underscore its progress, one related to its strengthened financial position and another highlighting its acceptance into a prestigious scientific seminar to present new research. These developments signal the company’s growth and its continued advancement toward commercializing its therapies.

One of the most significant challenges facing biotechnology companies is securing adequate funding to sustain research and development efforts. Calidi Biotherapeutics recently announced that it has strengthened its financial position, ensuring continued progress in its clinical and preclinical programs (https://ibn.fm/9JicX). As of Dec. 31, 2024, Calidi reported a cash balance of approximately $9.6 million. This increase is largely due to successful fundraising efforts, including proceeds from the company’s At-the-Market Offering Agreement (“ATM”).

As a result of these efforts, Calidi was able to terminate its Standby Equity Purchase Agreement (“SEPA”) with YA II PN Ltd., an affiliate of Yorkville Advisors, effective Jan. 23, 2025. The infusion of capital will allow the company to further refine its oncolytic virotherapy platforms, expand its clinical trials, and enhance its overall operational stability.

Additionally, Calidi announced the successful closing of a public offering on Jan. 10, 2025, which raised an additional $4.25 million in gross proceeds. This contributes to the ongoing development of Calidi’s proprietary technologies and supports the company’s mission to bring effective cancer therapies to market. This improved financial footing not only reassures investors but also allows Calidi to focus on achieving key milestones in its research pipeline. With adequate funding in place, the company is well-positioned to continue its groundbreaking work in cancer immunotherapy.

Beyond its financial achievements, Calidi Biotherapeutics has also made headlines for its acceptance into a major scientific conference where it will present its latest research findings (https://ibn.fm/WZ1RO). The company announced that it has been selected to present new data on its RTNova systemic virotherapy platform at the prestigious American Association for Cancer Research (“AACR”) annual meeting in April 2025.

This recognition marks an important milestone for Calidi, as the AACR annual meeting is one of the most influential conferences in the field of cancer research. Being accepted to present at this event underscores the significance of Calidi’s work and its potential to revolutionize cancer treatment.

Calidi’s RTNova platform is designed to overcome the limitations of traditional virotherapy by enabling systemic delivery and enhancing the targeting of metastatic tumors. Antitumor virotherapies have long been recognized for their ability to selectively infect and kill cancer cells, but challenges such as immune system clearance and limited distribution have hindered their full potential. The RTNova platform addresses these challenges by utilizing an extracellular enveloped virus (“EEV”) as a delivery mechanism, allowing the therapeutic viruses to reach tumors more effectively while evading premature destruction by the immune system. These preclinical findings highlight the RTNova platform’s ability to effectively target and treat metastatic cancer cells and represent a significant advancement in the field of cancer virotherapy.

In addition to the RTNova platform, Calidi is actively developing other innovative therapies aimed at harnessing the immune system to combat cancer. The company’s approach to immunotherapy focuses on protecting the viral payload to enhance the efficacy of antitumor viruses, potentially improving outcomes for patients with hard-to-treat cancers.

With a strengthened financial position and the recognition of its research by a leading scientific organization, Calidi Biotherapeutics is poised for continued growth. The company’s ability to secure funding ensures that it can maintain momentum in its clinical and preclinical programs, while its acceptance into a high-profile scientific seminar validates the importance of its work. As Calidi moves forward, it is well-positioned to make a lasting impact in the biotechnology industry. With continued innovation and a strong financial foundation, the company is set to play a crucial role in the future of cancer immunotherapy.

For more information, visit www.CalidiBio.com.

NOTE TO INVESTORS: The latest news and updates relating to CLDI are available in the company’s newsroom at https://ibn.fm/CLDI

About MissionIR

MissionIR (“MIR”) is a specialized communications platform with a focus on assisting IR firms with syndicated content to enhance the visibility of private and public companies within the investment community. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, MIR is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, MIR brings its clients unparalleled recognition and brand awareness.

MIR is where breaking news, insightful content and actionable information converge.

For more information, please visit www.MissionIR.com

Please see full terms of use and disclaimers on the MissionIR website applicable to all content provided by MIR, wherever published or re-published: https://www.MissionIR.com/Disclaimer

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www.MissionIR.com
310.299.1717 Office
Editor@MissionIR.com

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• According to the American Cancer Society, cancer is the second leading cause of death globally.
• Oncology drugs are a cornerstone of modern cancer treatment.
• Calidi Biotherapeutics is a cutting-edge biotechnology company dedicated to developing innovative cancer treatments.

Cancer continues to be one of the most significant health challenges of our time, with its global impact growing every year. The increasing number of cancer diagnoses and related deaths underscores the urgent need for more effective treatments, including advanced oncology drugs. Companies such as Calidi Biotherapeutics (NYSE American: CLDI) are at the forefront of research and development, offering hope for millions of patients worldwide.

According to the American Cancer Society, cancer is the second leading cause of death globally, with 2,001,140 new cancer cases and 611,720 cancer deaths projected to occur in the United States in 2024 (https://ibn.fm/JA0DN). Approximately one in six deaths worldwide is due to cancer. The global cancer burden is expected to rise to 28.4 million cases by 2040, a 47% increase from 2020. This surge is driven by population growth, aging, and lifestyle factors such as tobacco use, poor diet, and physical inactivity.

Among the most prevalent and deadly forms of cancer are lung cancer, which is responsible for 1.8 million deaths annually, making it the leading cause of cancer-related mortality (https://ibn.fm/woQzB); colorectal cancer, which accounts for nearly 935,000 deaths each year (https://ibn.fm/ms7ty); breast cancer, the most commonly diagnosed cancer, with more than 2.3 million new cases annually (https://ibn.fm/O313h); and stomach and liver cancers, which account for approximately 968,784 (https://ibn.fm/zyWfM) and 866,136 deaths per year, respectively (https://ibn.fm/4EvTp).

These statistics highlight the enormous need for effective cancer treatments, especially for high-mortality cancers such as glioblastoma (“GBM”), triple-negative breast cancer (“TNBC”), sarcoma and certain types of lung cancer.

Oncology drugs are a cornerstone of modern cancer treatment. These drugs range from traditional chemotherapy to targeted therapies and immunotherapies, which aim to enhance the body’s immune response against cancer cells. Oncology drugs play a vital role in:

• Extending Survival: Many advanced therapies have significantly improved survival rates for cancers once considered untreatable.
• Improving Quality of Life: Targeted treatments and immunotherapies often come with fewer side effects than traditional chemotherapy, allowing patients to maintain a better quality of life.
• Personalized Medicine: Advances in genetic testing have enabled the development of personalized oncology drugs tailored to the unique genetic makeup of a patient’s tumor.

The global oncology drug market was valued at approximately $158 billion in 2022 and is projected to reach $327 billion by 2037, reflecting a compound annual growth rate (“CAGR”) of 7.5% (https://ibn.fm/xBVyH). However, despite these advances, significant gaps remain in treatment efficacy, accessibility, and affordability, underscoring the urgent need for continued innovation.

Calidi Biotherapeutics is a cutting-edge biotechnology company dedicated to developing innovative cancer treatments. Their unique approach leverages antitumor virotherapies and patented technologies designed to protect and potentiate the virotherapy during administration to combat cancer more effectively and with fewer side effects. Calidi’s therapeutic strategy centers on harnessing the power of antitumor virotherapies, which are engineered to selectively infect and destroy cancer cells while sparing healthy tissue.

To enhance the delivery and efficacy of these viruses, Calidi uses extracellular enveloped viruses in its systemic platform and stem cells in its intratumoral platforms to protect the virotherapy from the body’s immune system during administration. The company’s dual approach offers multiple advantages, including targeted tumor destruction, in which viruses directly attack cancer cells, leading to their destruction; and immune system activation, a process that triggers a systemic immune response and trains the immune system to recognize and attack cancer cells throughout the body.

Calidi’s robust pipeline includes three key product candidates:

• RTNova (“CLD-400”): Targeting lung cancer and metastatic cancer, RTNova is a systemic platform that can be administered intravenously. The technology includes a vaccinia virus enveloped with a human cell membrane designed to protect the viral payload from the body’s immune system during administration and home in on cancer cells.
• SuperNova (“CLD-201”): Targeting solid tumors such as head and neck, triple-negative breast cancer and soft tissue sarcoma, SuperNova combines mesenchymal stem cells with vaccinia viruses. This therapy aims to overcome the limitations of traditional treatments by directly targeting tumors and activating the immune system.
• NeuroNova (“CLD-101”): This therapy is designed for patients with glioblastoma and other high-grade gliomas. It utilizes neural stem cells to deliver antitumor viruses directly to brain tumors, offering a promising new approach for one of the most aggressive and treatment-resistant cancers.

Calidi is also developing next-generation engineered antitumor viruses to broaden the scope of cancers treatable with its platform.

The groundbreaking work being done by Calidi Biotherapeutics has the potential to transform the oncology drug market and significantly improve cancer care. By focusing on high-need cancer types such as GBM, TNBC, sarcoma and lung cancer, Calidi addresses critical gaps in current treatment options. The company’s innovative therapies not only aim to improve survival rates but also reduce the debilitating side effects associated with many existing cancer treatments. As Calidi’s products advance through clinical trials, they hold the promise of offering new hope to patients facing some of the most challenging cancers.

The global burden of cancer continues to grow, making the need for effective oncology drugs more pressing than ever. As a leader in innovative cancer treatment, Calidi Biotherapeutics is poised to play a pivotal role in shaping the future of oncology drug development. Its pioneering therapies represent a new frontier in the fight against cancer, offering hope for improved outcomes and a better quality of life for millions of patients worldwide.

For more information, visit www.CalidiBio.com.

NOTE TO INVESTORS: The latest news and updates relating to CLDI are available in the company’s newsroom at https://ibn.fm/CLDI

About MissionIR

MissionIR (“MIR”) is a specialized communications platform with a focus on assisting IR firms with syndicated content to enhance the visibility of private and public companies within the investment community. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, MIR is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, MIR brings its clients unparalleled recognition and brand awareness.

MIR is where breaking news, insightful content and actionable information converge.

For more information, please visit www.MissionIR.com

Please see full terms of use and disclaimers on the MissionIR website applicable to all content provided by MIR, wherever published or re-published: https://www.MissionIR.com/Disclaimer

MissionIR
Los Angeles, CA
www.MissionIR.com
310.299.1717 Office
Editor@MissionIR.com

MissionIR is powered by IBN